E-DRUG: E-DRUG Amoebic Dysentery during pregnancy

["Antonio Addis" <addis@irfmn.mnegri.it>]

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E-DRUG Amoebic Dysentery during pregnancy

The drug of choice for treating amebiasis (particulary during the first
trimester).


The drug of choice for treating amebiosis is determined  by the type of
infection. For intestinal amebiosis with dysentery, drugs of choise are
metronidazole followed by iodoquinol or another intraluminal drug. The use
of metronodazole in pregnancy is controversial. The drug  is mutagenic in
bacteria and carcinogenic in rodents, and although these properties have
never been shown in humans, concern for these toxicities have led some to
advise against the use metronidazole. In summary, althought the available
reports have arrived at conflicting conclusions, up to day there are no
evidence prouving that these treatments increase the risk of major
malformations in newborns exposed in utero.  
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Chiara Ottolini
Regional Drug Information Center (C.R.I.F)
Laboratory for Mother and Child Health
Istituto di Ricerche Farmacologiche "Mario Negri"
via Eritrea 62, 20157
Milano, Italy
Phone +39+2+39014559
Fax      +39+2+3559024
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