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Re: E-DRUG: E-DRUG Demazin Syrup Response

  • Subject: Re: E-DRUG: E-DRUG Demazin Syrup Response
  • From: James McCormack <[email protected]>
  • Date: Tue, 2 Jun 1998 09:17:51 -0400 (EDT)
***************************************
E-DRUG Demazin Syrup Response

To date, as far as I'm aware, there are no studies that show any cold
preparations (antihistamine/decongestant combinations)  or cough
preparations (DM, codeine etc) work in children under the age of 6. In
contrast 3 studies have shown that they don't work (Randall 1979 in
Pediatrics, Hutton 1991 in J Pediatr, Taylor 1993 in J Pediatr). In
addition, in B.C., cold remedies are involved in approximately 20% of cases
of pharmaceutical overdoses in children less than 4, they are easily
administered incorrectly, and paradoxical reactions have been reported. If
anyone has any information to the contrary please let me know. Thanks.

At 08:44 AM 01/06/98 -0400, you wrote:
>*****************************************
>E-DRUG Demazin Syrup
>
>Demazin Syrup is sold in South Africa by Schering Plough for allergic
>conditions. It contains per 5 mls:
>
>cholrpheniramine malate 1.25 mg
>
>phenylephrine hydrochloride 2.5 mg
>
>alcohol 7.5% v/v
>
>Preservatives:  Methylparaben  0.05 m/v
>                       Propylparaben 0.01 m/v
>
>I should be most grateful for comments on the logic of this combination or
>any risks associated with it including the preservatives.
>
>Looking through UK information I can find some data on phenylephrine as a
>topical drug and as an inhalant but not as an oral compound.  Is the above
>combinations licensed for use in any developed country or is phenylephrine
>licensed for oral use orally?  Or is this a combination licensed and sold
>mainly in developing countries?
>
>In South Africa it is licensed for use in children under 1 at 1.25 ml  and
>1-3 up to 5 ml bd.
>
>Dr Ian Roberts
>Special Advisor to the Minister of Health
>[email protected]
>
>
>--
>Send mail for the `E-Drug' conference to `[email protected]'.
>Mail administrative requests to `[email protected]'.
>For additional assistance, send mail to:  `[email protected]'.
>
James McCormack, Pharm.D.
Associate Professor
Clinical Division Chair
Faculty of Pharmaceutical Sciences
c/o Pharmacy Department
St. Paul's Hospital
1081 Burrard St.
Vancouver, B.C.
Canada
V6Z 1Y6
604-631-5150 Fax 604-631-5154



--
Send mail for the `E-Drug' conference to `[email protected]'.
Mail administrative requests to `[email protected]'.
For additional assistance, send mail to:  `[email protected]'.