E-DRUG: Dipyrone

["F. Cankat Tulunay" <F.Cankat.Tulunay@pallas.dialup.ankara.edu.tr>]

E-drug: Dipyrone
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Dear E-druggers,

Since quite some time our group has been working on different aspects
of dipyrone both in animals and in humans. In recent years several
groups, including ours, showed that it is a powerful analgesic and
antipyretic compound with central action. This year we showed that
dipyrone has unique action on smooth muscle and its antispasmodic
effects related with this muscle relaxing action. We are going to
publish our results in very near future. So far we did not see any
serious side effects in clinical trials. Of course the drug has some side
effects and it may cause agranulocytosis in some patients, as with
aspirin and other NSAIDs. On the other hand paracetamol
(acetaminophen) is much more toxic than dipyrone and, ironically, it is
an OTC compound.

Our research with dipyrone is going on. According to our recent
findings it is effective in terminal cancer patients tolerant to opioid
and suffering from intractable pain. When we applied dipyrone with a
special technique it is effective even in these patients. I will present
some of our recent findings at the 3rd European Headache Congress
(Corfu, June 1998).

For these and several other reasons I believe Dipyrone should be
available in every country.

With my best regards

F. Cankat Tulunay, M.D., Ph.D.
Prof of Clinical Pharmacology and Headache Research Center
Chairman of European Headache Federation Drug Committee
e-mail: F.Cankat.Tulunay@pallas.dialup.ankara.edu.tr
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